Early, novel study suggests that nerve fibers may be better off without myelin after immune-mediated damage in MS
July 6, 2023
Myelin is the substance that surrounds axons (nerve fibers) and is generally thought to be protective and supportive. New research from teams in Germany shows that axons were more likely to degrade in the presence of myelin that had been damaged, rather than if myelin was completely lost. These data were obtained from tissue samples from four people with MS and from mouse models of MS-like disease. They suggest that myelin (and oligodendrocytes, the cells that make myelin) may not be able to support axons after experiencing immune-mediated damage, but rather, may harm the axons instead.
This novel idea requires much further study, but if confirmed, presents a novel direction for
restoring what’s been lost in MS.
Read more about this study from the University of Leipzig
Read the study, available in Nature Neuroscience via Open Access
Multiple sclerosis is an unpredictable disease of the central nervous system. Currently there is no cure. Symptoms vary from person to person and may include disabling fatigue, mobility challenges, cognitive changes, and vision issues. An estimated 1 million people live with MS in the United States. Early diagnosis and treatment are critical to minimize disability. Significant progress is being made to achieve a world free of MS.
The National MS Society, founded in 1946, is the global leader of a growing movement dedicated to creating a world free of MS. The Society funds cutting-edge research for a cure, drives change through advocacy and provides programs and services to help people affected by MS live their best lives. Connect to learn more and get involved: nationalMSsociety.org, Facebook, X, formerly known as Twitter, Instagram, YouTube or 1-800-344-4867.