New Research: How EBV May Trigger MS
May 19, 2023
New research shows one possible way that the Epstein Barr virus (EBV) could trigger MS. A research team from Sweden looked at blood samples from 713 people with MS and 722 people without MS. The results showed that 23% of those with MS had antibodies in their blood that reacted to both a protein on EBV and to a protein found in the brain and spinal cord, while only 7% of people without MS had these “cross reactive” antibodies.
Other studies have identified other potential cross-reactivities to molecules in the brain and spinal cord and components of EBV. If this triggers immune activity misdirected against the body’s own brain and spinal cord tissues, it may contribute to inflammation and damage, bringing on MS in those who are susceptible.
Why does this matter? This study adds to growing evidence about the likely role of EBV in triggering MS when other MS risk factors are present. Ongoing research should help decipher the mechanisms of how EBV is involved and how they may be different among individuals.
Read more about this study from Karolinska Institutet
Read the study in Science Advances
Read about the complex link between MS and EBV from Momentum Magazine
Watch a webinar, Ask an MS Expert: The Role of Epstein-Barr Virus in MS
Multiple sclerosis is an unpredictable disease of the central nervous system. Currently there is no cure. Symptoms vary from person to person and may include disabling fatigue, mobility challenges, cognitive changes, and vision issues. An estimated 1 million people live with MS in the United States. Early diagnosis and treatment are critical to minimize disability. Significant progress is being made to achieve a world free of MS.
The National MS Society, founded in 1946, is the global leader of a growing movement dedicated to creating a world free of MS. The Society funds cutting-edge research for a cure, drives change through advocacy and provides programs and services to help people affected by MS live their best lives. Connect to learn more and get involved: nationalMSsociety.org, Facebook, X, formerly known as Twitter, Instagram, YouTube or 1-800-344-4867.