Clinical Trial: Efficacy of Diet on Quality of life in MS

Funding:

Carter Chapman Shreve Family Foundation

Description

We are recruiting for a new study that is being conducted at the University of Iowa! 

People affected by relapsing remitting multiple sclerosis who are between the ages of 18 and 70 are invited to participate to evaluate the effects of three diets — Modified Paleolithic Elimination diet, Time Restricted Olive Oil-based Ketogenic diet, and your usual diet with the addition of educational materials. Participants in the usual diet group will receive educational information and determine if they would like to make any changes based on the recommendations provided. We will look at the effects of diet on quality of life, including motor and vision function, fatigue, mood, and disease activity. This will be assessed by online surveys, study participant tasks, and brain imaging. 

Participants who have expressed interest in a dietary approach to  reduce their disease symptoms and improve the quality of life will be randomized to one of the three diets. The Modified Paleolithic Elimination (MPE) diet excludes all gluten, dairy, and eggs and increases daily intake of fruits and vegetables. The Time Restricted Olive Oil-based (TROO) Ketogenic diet limits carbohydrates to less than 50 grams per day, uses olive oil to increase fat intake, and includes non-starchy vegetables daily. Participants following their usual diet will be given information and resources that limits sodium, encourages servings of fruits, vegetables, whole grains, and reduced-fat dairy products.
 
We anticipate  that all three groups will experience some level of improvement in their quality of life and or reduced fatigue. 

The study will be conducted at the University of Iowa Hospitals and Clinics in Iowa City, Iowa 52242. 

Participants will be followed for two years. In person visits will occur at baseline, month 3, and end of study (month 24).

Blood draws and saliva will be collected at baseline, month 3, and end of study (month 24). 

Non-contrast (that is no gadolinium will be used) brain MRIs will be obtained at baseline and end of study (month 24). 
 
If you would like to be a part of our research registry and screen to see if you are eligible for our new study  copmlete the brief survey. https://redcap.icts.uiowa.edu/redcap/surveys/?s=JX73EYRJNPF9MHRR  

The form asks for basic information about yourself and if you would like to be contacted in the future and be part of our research registry.   If you are eligible for the  strudy the research team will contact you to explain the study in more detail. There is no obligation to participate in future studies you are not interested in. 

If you have questions, please feel free to contact us at MSDietStudy@healthcare.uiowa.edu.