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COVID-19 Vaccines for Children and Adolescents with MS and Related Disorders


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Updated: May 11, 2023

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The following guidance for children and adolescents applies to vaccines currently authorized or approved for their age.

Infants, children and adolescents aged 6 months to 17 years should be vaccinated against COVID-19

The science has shown that the COVID-19 vaccines are safe and effective. The American Academy of Pediatrics recommends COVID-19 vaccination for all infants, children and adolescents 6 months of age and older who do not have medical reasons that make receiving a COVID-19 vaccine unsafe. Vaccination of infants, children and adolescents brings us one step closer to ending this pandemic and is an additional layer of protection for the most vulnerable among us.

Infants, children and adolescents are at risk of severe illness from COVID-19

COVID-19 can cause serious illness in all persons, including those under age 18 years. While most cases of COVID-19 in infants, children and adolescents are mild, some are severe or even fatal. In addition to health risks due to COVID-19, children and adolescents are at risk for multisystem inflammatory syndrome in children (MIS-C) that can occur 2 to 6 weeks after COVID-19.

MIS-C is a condition that can occur after COVID-19 in which different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes or gastrointestinal organs. MIS-C is serious, even deadly, although with prompt and often intensive care, most children and adolescents with MIS-C in the U.S. survive.

Infants, children and adolescents with MS and related conditions should be vaccinated against COVID-19

The importance of COVID-19 vaccination for infants, children and adolescents with MS and related disorders mirrors the advice for infants, children and adolescents in general. While MS is extremely rare in young children, other forms of brain, optic nerve and spinal inflammation can occur. To date, there is no evidence that children and adolescents with MS experience more severe COVID-19, nor that they are at higher risk for MIS-C due to COVID-19 compared to children and adolescents who do not have MS. For all infants, children and adolescents, vaccination is strongly encouraged. Like other medical decisions, the decision to get a vaccine is best made in partnership with your healthcare provider.

Risk of complications from COVID-19 is higher than of any potential complications from the vaccine

Studies have found more complications, like myocarditis, MIS-C and demyelinating events, after children and adolescents have COVID-19 than following COVID-19 vaccination. The benefits of vaccination outweigh any potential risks. Review Center for Disease Control and Prevention (CDC) guidance on vaccination for those who have had COVID-19 or MIS-C.

COVID-19 vaccines do not affect fertility

The American College of Obstetricians and Gynecologists are confident the COVID-19 vaccines do not affect fertility. They base this on the science of how the vaccines are made and studies that have confirmed this. The American Academy of Pediatrics (AAP) also affirms that getting vaccinated against COVID-19 does not interfere with girls’ or boys’ future fertility. Watch this short video from the AAP to learn more.

The COVID-19 vaccines are not expected to cause MS or trigger an MS relapse

None of the available vaccines contain live virus and the vaccines will not cause COVID-19. The vaccines have been studied in large numbers of people with MS and they did not trigger an MS relapse. The risk of getting COVID-19 far outweighs any risk of having an MS relapse from the vaccine. Learn more about the different types of vaccines and how they work from the CDC.

Any vaccine can cause side effects, including a fever. A fever can make MS symptoms worse temporarily, but they should return to prior levels after the fever is gone. Even if side effects occur, it’s important to get all the doses required for your vaccine for it to be effective.

Children and adolescents who use medications to manage MS and related disorders should be vaccinated

Some medications used for MS and related disorders may affect responses to the vaccines. Coordinating the timing of vaccine administration with these DMTs may provide the best vaccine response. Given the potential serious health consequences of COVID-19, getting the vaccine as soon as possible may be more important than optimally timing the vaccine with your DMT. Work with your MS healthcare provider to determine the best schedule for you. Review our guidance on timing MS medications with these vaccines. 

Individuals consulted in the development of this guidance

The National MS Society consulted the following individuals in the development of this guidance:

MS neurologists and pediatric experts

  • Nancy Sicotte, MD, FAAN — Chair, National MS Society’s National Medical Advisory Committee, Cedars-Sinai Medical Center, USA
  • Brenda Banwell, MD — Chair, MS International Federation International Medical and Scientific Advisory Board (IMSB) — University of Pennsylvania, USA
  • Maria Pia Amato, MD — University of Florence, Italy
  • Amit Bar-Or, MD, FRCPC — President, International Society for Neuroimmunology, University of Pennsylvania, USA
  • Tanuja Chitnis, MD — Harvard Medical School, Massachusetts General Hospital, USA
  • Jorge Correale, MD — Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina
  • Anne Cross, MD, FAAN — Washington University and Secretary of Board of Governors of the Consortium of MS Centers, USA
  • Jaime Imitola, MD, FAAN — University of Connecticut, UConn Health, USA
  • Cheryl Hemingway, MBChB, PhD — Great Ormond Street Hospital for Children, UK
  • Dorlan Kimbrough, MD — Duke University, USA
  • Professor Deiva Kumaran — Paris South University Hospitals, France
  • Avindra Nath, MD — National Institutes of Health/National Institutes of Neurological Disorders and Stroke, USA
  • Scott Newsome, DO, MSCS, FAAN, FANA — Johns Hopkins University and President of the Board of Governors of the Consortium of MS Centers, USA
  • Daniela Pohl, MD, PhD — University of Ottawa, Canada
  • Kevin Rostasy, MD — Children’s Hospital Datteln, University Witten/Herdecke, Germany
  • Penny Smyth, MD, FRCPC — University of Alberta, Canada
  • Rachael Stacom, MS, ANP-BC, MSCN — Independence Care System, USA
  • Silvia Tenembaum, MD — Pediatric Hospital Dr. J. P. Garrahan, Buenos Aires, Argentina
  • Dr. Evangeline Wassmer — Birmingham Women and Children’s Hospital, UK
  • Emmanuelle Waubant, MD, PhD — University of California San Francisco, USA

Staff from MS partner organizations

  • Julie Fiol, RN, MSCN — National MS Society, USA
  • Pamela Kanellis, PhD — MS Society of Canada
  • Julie Kelndorfer — MS Society of Canada
  • Hope Nearhood, MPH, PMP — National MS Society, USA
  • Leslie Ritter — National MS Society, USA


© 2024 The National Multiple Sclerosis Society is a tax exempt 501(c)3 nonprofit organization. Its Identification Number (EIN) is 13-5661935.